Therapy-related acute myeloid leukaemia following immunosuppression with azathioprine for polymyositis.
نویسندگان
چکیده
A 52-year-old man developed therapy-related acute myeloid leukemia (AML) following prolonged immunosuppression with azathioprine for polymyositis. Karyotypic analysis showed deletions of the short arm of chromosome 7 and the long arm of chromosome 5. The importance of recognizing this potential complication while treating benign rheumatological and immunological diseases with purine analogues like azathioprine is emphasized. Therapy-related AML is a poor prognostic group that does not respond favourably to standard induction therapy.
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عنوان ژورنال:
- Clinical and laboratory haematology
دوره 16 3 شماره
صفحات -
تاریخ انتشار 1994